Female infertility

Povratak na Sterilitet

A woman’s reproductive system is extremely complex and complex. A large number of organs and organ systems are involved in achieving a single goal, and that is the production of a normal egg cell. From the brain, circulatory, immune system, through the glands to the reproductive organs such as the ovary, fallopian tubes and uterus. How complex and intertwined this system and process is can be seen from the following. In order to produce an egg, certain parts of the brain need to produce the appropriate hormones. Then, in order for hormones to perform their function, there must be appropriate receptors. These are the molecules that capture them. Therefore, normal circulation is required. Proper ovarian function is also required. And from several aspects. Hormonal, structural, and regulatory. To react to certain growth factors in order for follicles to develop and an egg to form. An appropriate balance of hormones is also needed in order for the reproductive cycle to be normal and ovulation to occur. And so on and so forth.

This system is sensitive as it is complex and is such if any part of it fails then the results is usually female infertility.

Factors that can cause improper functioning of the reproductive system in women, i.e. infertility, can be divided into two groups. These are EXTERNAL and INTERNAL


infections, radiation, smokling, drugs, trauma and so on.


INTERNAL or ENDOGENOUS are at the same as genetic. Namely, a woman’s entire reproductive system is controlled by genes which encode for: hormones, receptors, growth factors, ovaries, fallopian tubes, and the uterus. Any malfunction of the genes in this chain causes infertility. It’s a huge number of different genes. But in a certain person, with appropriate clinical trials and genetic analysis of a given condition, responsible genes can be uncovered. This is an extremely important and significant approach in the treatment of infertility. Because establishing the real cause of infertility is a path to finding much more successful and simpler treatment. Also, what is especially important with this approach in the treatment of infertility is the reduction of the risk of applying unwanted or wrong therapy. Which can sometimes cause irreversible changes in terms of a certain change in metabolism, hormonal issues, the appearance of other concomitant diseases and the like.

Therefore, in developed countries, the following approach in the treatment of sterility has recently been in circulation. Along with clinical trials of sterility, there is a genetic evaluation of the married couple and, if necessary, targeted genetic tests are performed. Not any genetic tests, but an appropriate tailored genetic test that solves the specific problem related to a certain married couple. The results are much more positive because of this approach. The true cause of infertility can be diagnosed. Thus, the treatment is much more successful. Symptomatic treatment of sterility is simply not approached. So if you are struggling with sterility, you are doing genetics along with clinical trials and analyzes. And the first thing is genetic counseling. To clarify everything and perform a complete evaluation of genetic status. And after that, if you get a valid explanation that is understandable to you, do a targeted genetic test. And you try to combine clinical analyzes and harmonize them with genetic results. If you succeed in this, the results will be much more successful.

Today, there are genetic tests that can precisely diagnose certain problems related to male sterility. You should also know that there are cases when a genetic test is not necessary and obligatory. Because after genetic counseling, valid information can be obtained that can solve the problem of sterility for a certain married couple.

It is proven that CLINICAL INVESTIGATIONS INTO AND GENETIC COUNSELING FOR INFERTILITY are the best corse of action that can be taken when facing this issue. This is the common approach in most developed countries.

You can read the following article for more:  Rolf-Dieter Wegner Matthias Bloechle Genetic testing in couples with infertility  Zentrum für Pränataldiagnostik, Kudamm 199 und Institut

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Povratak na Sterilitet